What they did: Followed 152 people with POTS over 10 years at the Mayo Clinic.

What they found:

•  About half had mild nerve damage in their legs (“neuropathic POTS”), which makes blood pool there when you stand.
•  Around one in seven had antibodies that attacked their nerves (“autoimmune POTS”).
•  Others fell into “hyperadrenergic” (extra stress hormones) or “hypovolemic” (low blood volume) groups.Why it matters for you: Knowing your POTS type can guide treatment—if you’re low on blood volume, increasing 􀀁uids and salt helps; if you have nerve issues, compression stockings and medications that tighten blood vessels may be best; if it’s autoimmune, some people even bene􀀂t from immune‑modulating therapies.

🔗 Read more: https://doi.org/10.4065/82.3.308